Module 5, 'Acid-base reactions', discusses acid-base reactions from the basics to the details of how molecular structure affects acidity and basicity . The focus is the relationship between form and function, rather than on detailed reaction mechanisms.
Module 5 references chapter 7 of Soderberg. Big ideas:
1. Acid strength (pKa) predicts the direction (equilibrium) of acid-base reactions. 2. An acid's strength increases with the stability of its conjugate base. Module 5 slide sets: Acid-base reactions
(Click on the links below to download each slide set for the lecture.) Introduction: proton jumping, the Grotthuss mechanism 5.1: Acid-base reactions 5.1A: The Brønsted-Lowry definitions 5.1B: The Lewis definitions 5.2: Comparing acid-base nature of functional groups (Ka) 5.2A: Defining Ka and pKa 5.2B: Using pKa to predict reaction equilibria 5.2C: Buffered solutions: Henderson-Hasselbach 5.3: Structural effects on acidity and basicity 5.3A: Periodic trends 5.3B: Resonance effects 5.3C: Inductive effects 5.4: Acid-base properties of phenols 5.5: Acid-base properties of N-containing functional groups 5.5A: Anilines 5.5B: Imines 5.5C: Pyrroles 5.6: Carbon acids 5.6A: The acidity of ⍺-protons 5.6B: Keto-enol tautomers 5.6C: Imine-enamine tautomers 5.6D: The acidity of terminal alkynes 5.7: Polyprotic acids 5.8: Effects of enzymatic microenvironment on acidity and basicity Resources for students:
> Module 5 lecture outline (PDF) > Module 5 lecture with instructor's notes (PDF) > Module 5 key concepts > Module 5 practice problems > Practice problems KEY > pKa tables > Amino acid pKa and pI values > Guide to using the Henderson-Hasselbalch equation > Electron donating and withdrawing groups > Acid-base reaction mechanism animation |
*Assignments:
> Homework set 5 > Acid-base equilibrium WS |
Video tutorials for Module 5:
> Acid-base chemistry (Khan Academy)
> VIDEO: Proton hopping in small water cluster (CanSimulations)
> VIDEO: Proton jumping simulation (Cliff Pickover)
> Acid-base chemistry (Khan Academy)
> VIDEO: Proton hopping in small water cluster (CanSimulations)
> VIDEO: Proton jumping simulation (Cliff Pickover)